Histopathological and immunohistochemical investigation of the effect of Shilajit in rats with experimental spinal cord injury

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dc.authoridSANCAK, TUNAHAN/0000-0002-7813-1575
dc.contributor.authorCetin, Eyup
dc.contributor.authorSancak, Tunahan
dc.contributor.authorKeles, Omer Faruk
dc.contributor.authorUnlu, Ilker
dc.contributor.authorAkyol, Mehmet Edip
dc.contributor.authorArabacı, Ozkan
dc.date.accessioned2025-03-26T17:34:51Z
dc.date.available2025-03-26T17:34:51Z
dc.date.issued2023
dc.departmentİstanbul Esenyurt Üniversitesi
dc.description.abstractBACKGROUND: This experimental study was designed to investigate the histopathological and immunohistochemical effects of Shilajit in rats with experimentally induced spinal cord injury (SCI). METHODS: The rats were divided into three groups: Control group: The group in which spinal cord damage was created but no drug was administered. Low-dose group: This is the group in which intraperitoneal Shilajit is given at a dose of 150 mg/kg at the 1st h, 1st day, 2nd day, and 3rd day after spinal cord damage was induced. High-dose group: This is the group in which intraperitoneal Shilajit is given at a dose of 250 mg/kg at the 1st h, 1st day, 2nd day, and 3rd day after spinal cord damage was induced. Thin sections taken from the spinal cord after euthanasia were sent for histopathological and immunohistochemical examination. RESULTS: Histopathological examination of the high-dose group showed lower amounts of morphological findings compared to the low-dose group and control group. While a significant CD68 immune reaction was observed in the control group of rats with spinal injury, the positive immune reaction was found to be significantly decreased in the Shilajit-applied groups. CONCLUSION: It is thought that the use of Shilajit in SCI will reduce the effects of secondary damage in SCI and that its administration to such patients will have positive effects on the results.
dc.identifier.doi10.14744/tjtes.2023.60621
dc.identifier.endpage1334
dc.identifier.issn1306-696X
dc.identifier.issn1307-7945
dc.identifier.issue12
dc.identifier.pmid38073457
dc.identifier.scopus2-s2.0-85179357879
dc.identifier.scopusqualityQ3
dc.identifier.startpage1329
dc.identifier.trdizinid1263576
dc.identifier.urihttps://doi.org/10.14744/tjtes.2023.60621
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1263576
dc.identifier.urihttps://hdl.handle.net/20.500.14704/932
dc.identifier.volume29
dc.identifier.wosWOS:001125282700002
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTurkish Assoc Trauma Emergency Surgery
dc.relation.ispartofUlusal Travma Ve Acil Cerrahi Dergisi-Turkish Journal of Trauma & Emergency Surgery
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20250326
dc.subjectExperimental study; primary injury; secondary injury; shilajit; spinal cord paralysis; spinal cord injury
dc.titleHistopathological and immunohistochemical investigation of the effect of Shilajit in rats with experimental spinal cord injury
dc.typeArticle

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