Exploring the interplay of selenoproteins and mir-675 in breast cancer: a focus on radiotherapy effects

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dc.authoridAydemir, Birsen/0000-0003-1406-864X
dc.authoridHaciosmanoglu, Ebru/0000-0001-9559-4515
dc.contributor.authorDegirmencioglu, Sevgin
dc.contributor.authorOgut, Selim
dc.contributor.authorBahtiyar, Nurten
dc.contributor.authorAydemir, Birsen
dc.contributor.authorKaracetin, Didem
dc.contributor.authorCinemre, Fatma Behice
dc.contributor.authorHaciosmanoglu Aldogan, Ebru
dc.date.accessioned2025-03-26T17:34:58Z
dc.date.available2025-03-26T17:34:58Z
dc.date.issued2025
dc.departmentİstanbul Esenyurt Üniversitesi
dc.description.abstractObjectivesThe present study aims to investigate the changes in the expression levels of miR-675 and some selenoproteins (Sel K, Sel W, and Sel P) in patients with breast cancer, before and after radiotherapy.Subjects and methodsThis study included 35 breast cancer patients who applied to the Department of Radiation Oncology for radiotherapy and 25 healthy female controls. miR-675 expressions were analyzed by using quantitative reverse-transcription polymerase chain reaction (qRT-PCR). Western blot was conducted to determine Sel K, Sel W, and Sel P expression levels. Biochemical parameters and complete blood count were analyzed by autoanalyzer system and automatic cell counter, respectively.ResultsPlasma Sel K protein expression levels were decreased in the after-radiotherapy group compared to the control and before-radiotherapy groups, but plasma miR-675 expression levels were lower in both before and after radiotherapy groups compared to the control group.ConclusionOur findings showed that miR-675 and Sel K expression levels changed after radiotherapy in breast cancer patients. These changes may have the potential to be biomarkers for the effectiveness of radiotherapy in breast cancer.
dc.description.sponsorshipScientific Research Projects Unit of Idot;stanbul University [38056]
dc.description.sponsorshipThis study was supported by the Scientific Research Projects Unit of & Idot;stanbul University, Project number: 38056.
dc.identifier.doi10.1080/09553002.2025.2473962
dc.identifier.issn0955-3002
dc.identifier.issn1362-3095
dc.identifier.pmid40043235
dc.identifier.scopus2-s2.0-86000445883
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1080/09553002.2025.2473962
dc.identifier.urihttps://hdl.handle.net/20.500.14704/977
dc.identifier.wosWOS:001437519500001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTaylor & Francis Ltd
dc.relation.ispartofInternational Journal of Radiation Biology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20250326
dc.subjectBreast cancer; mir-675; radiotherapy; selenoproteins
dc.titleExploring the interplay of selenoproteins and mir-675 in breast cancer: a focus on radiotherapy effects
dc.typeArticle

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