Decreasing myocardial estrogen receptors and antioxidant activity may be responsible for increasing ischemia- and reperfusion-induced ventricular arrhythmia in older female rats

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dc.authoridOzarslan, Talat Ogulcan/0000-0002-2635-7011
dc.contributor.authorBozdogan, Omer
dc.contributor.authorBozcaarmutlu, Azra
dc.contributor.authorKaya, Salih Tunc
dc.contributor.authorSapmaz, Canan
dc.contributor.authorOzarslan, Talat Ogulcan
dc.contributor.authorEksioglu, Didem
dc.contributor.authorYasar, Selcuk
dc.date.accessioned2025-03-26T17:35:09Z
dc.date.available2025-03-26T17:35:09Z
dc.date.issued2021
dc.departmentİstanbul Esenyurt Üniversitesi
dc.description.abstractAims: This study aimed to investigate the relationship between ischemia- and reperfusion-induced arrhythmia and blood serum estrogen levels, myocardial estrogen receptor levels, antioxidant enzyme activities, and the effects of the estrogen receptor blocker, fulvestrant (ICI 182 780). Main methods: A total of 102 female Sprague-Dawley rats of different ages (2-3, 6-7, 14-15, and 20-21 months) were used in this study. Myocardial ischemia was produced by ligation of the descending branch of the left anterior descending coronary artery, and reperfusion was produced by releasing this artery. An electrocardiogram (ECG) and blood pressure were recorded for 6 min of ischemia and 6 min of reperfusion. The levels of superoxide dismutase (SOD), malondialdehyde (MDA), catalase (CAT), estrogen receptor alpha (ER alpha), and estrogen receptor beta (ER beta) in myocardial tissue and 17 beta-estradiol (E2) in blood serum were measured via enzyme-linked immunosorbent assay (ELISA). The results were compared using a Mann-Whitney U test, one-way analysis of variance (ANOVA), and a student's t-test. Key findings: It is not the changes in serum estrogen levels but the decreasing myocardial estrogen receptors and antioxidant activities that could be responsible for the occurrence of more severe arrhythmia in response to reperfusion in older female rats. Significance: The death rate due to a heart attack in younger men is higher than in women. However, it equalizes after the menopausal stage in women. In this study, the reason for the increasing sudden post-menopausal death rate in women was investigated experimentally.
dc.description.sponsorshipBolu Abant Izzet Baysal University Scientific Research Projects Coordination Unit Turkey [BAP-2016.03.01.998]
dc.description.sponsorshipThis work was supported by Bolu Abant Izzet Baysal University Scientific Research Projects Coordination Unit Turkey [grant number BAP-2016.03.01.998].
dc.identifier.doi10.1016/j.lfs.2021.119190
dc.identifier.issn0024-3205
dc.identifier.issn1879-0631
dc.identifier.pmid33571518
dc.identifier.scopus2-s2.0-85100632588
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1016/j.lfs.2021.119190
dc.identifier.urihttps://hdl.handle.net/20.500.14704/1069
dc.identifier.volume271
dc.identifier.wosWOS:000626600400027
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherPergamon-Elsevier Science Ltd
dc.relation.ispartofLife Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20250326
dc.subjectAging; Myocardial; Arrhythmia; Antioxidant; Rat
dc.titleDecreasing myocardial estrogen receptors and antioxidant activity may be responsible for increasing ischemia- and reperfusion-induced ventricular arrhythmia in older female rats
dc.typeArticle

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