Advanced glycation end products: understanding their health risks and effective prevention strategies

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dc.authoriderim, burak/0000-0003-1927-4549
dc.authoridBinici, Halil Ibrahim/0000-0003-3301-3994
dc.contributor.authorErim, Burak
dc.contributor.authorBinici, Halil İbrahim
dc.date.accessioned2025-03-26T17:34:56Z
dc.date.available2025-03-26T17:34:56Z
dc.date.issued2024
dc.departmentİstanbul Esenyurt Üniversitesi
dc.description.abstractAdvanced glycation end products (AGEs) are harmful compounds formed through non-enzymatic reactions between reducing sugars and proteins or lipids, and are linked to the progression of chronic diseases such as diabetes, cardiovascular disease, and neurodegenerative disorders. These compounds contribute to oxidative stress, inflammation, and accelerated aging at the cellular level. Studies indicate that elevated AGE levels are closely associated with worsened outcomes in these conditions, as they exacerbate oxidative stress and inflammation, further hastening disease progression. Emerging evidence also suggests that lifestyle interventions, including dietary adjustments and increased physical activity, can reduce AGE levels and enhance health outcomes. This review aims to explore the mechanisms through which AGEs affect health and assesses various strategies for reducing their impact. Future research should prioritize refining AGE detection techniques and developing novel interventions to mitigate their detrimental effects, with the goal of improving the prevention and management of chronic diseases.
dc.identifier.doi10.1186/s41110-024-00298-z
dc.identifier.issn2316-7874
dc.identifier.issue2
dc.identifier.scopus2-s2.0-85206483037
dc.identifier.scopusqualityQ4
dc.identifier.urihttps://doi.org/10.1186/s41110-024-00298-z
dc.identifier.urihttps://hdl.handle.net/20.500.14704/939
dc.identifier.volume49
dc.identifier.wosWOS:001332054600001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherSpringernature
dc.relation.ispartofNutrire
dc.relation.publicationcategoryDiğer
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20250326
dc.subjectAdvanced glycation end products; Chronic diseases; Oxidative stress; Inflammation; Lifestyle modifications
dc.titleAdvanced glycation end products: understanding their health risks and effective prevention strategies
dc.typeReview

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