Advanced glycation end products: understanding their health risks and effective prevention strategies
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Tarih
2024
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Springernature
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Advanced glycation end products (AGEs) are harmful compounds formed through non-enzymatic reactions between reducing sugars and proteins or lipids, and are linked to the progression of chronic diseases such as diabetes, cardiovascular disease, and neurodegenerative disorders. These compounds contribute to oxidative stress, inflammation, and accelerated aging at the cellular level. Studies indicate that elevated AGE levels are closely associated with worsened outcomes in these conditions, as they exacerbate oxidative stress and inflammation, further hastening disease progression. Emerging evidence also suggests that lifestyle interventions, including dietary adjustments and increased physical activity, can reduce AGE levels and enhance health outcomes. This review aims to explore the mechanisms through which AGEs affect health and assesses various strategies for reducing their impact. Future research should prioritize refining AGE detection techniques and developing novel interventions to mitigate their detrimental effects, with the goal of improving the prevention and management of chronic diseases.
Açıklama
Anahtar Kelimeler
Advanced glycation end products; Chronic diseases; Oxidative stress; Inflammation; Lifestyle modifications
Kaynak
Nutrire
WoS Q Değeri
N/A
Scopus Q Değeri
Q4
Cilt
49
Sayı
2
