Comparative analysis of regressive and non-regressive autism: a study of clinical patterns and environmental risk factors in Turkey

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dc.contributor.authorCevher Binici, Nagihan
dc.contributor.authorKutlu, Ayse
dc.contributor.authorYazan Songur, Cisel
dc.contributor.authorSabah Baris, Hande Emine
dc.date.accessioned2025-07-23T20:44:14Z
dc.date.available2025-07-23T20:44:14Z
dc.date.issued2025
dc.departmentİstanbul Esenyurt Üniversitesi
dc.description.abstractObjectiveThis study compared clinical features, symptom severity, and prenatal/perinatal risk factors in children with regressive (ASD-R) and non-regressive autism spectrum disorder (ASD-NR) in a Turkish paediatric sample.MethodA retrospective cross-sectional study was conducted with 143 children aged 2-6 years diagnosed with ASD, grouped as ASD-R (n = 29) or ASD-NR (n = 114). Symptom severity was assessed using the CARS, AuBC, and ABC. Data on prenatal and perinatal factors, epilepsy, and parental age were collected.ResultsNo significant differences were found in CARS, AuBC, or total ABC scores, except for higher lethargy/social withdrawal scores in the ASD-NR group. Prenatal and perinatal risk factors and epilepsy prevalence were similar. However, parental ages at birth were significantly higher in the ASD-R group. Logistic regression did not yield significant predictors of regression.ConclusionThe findings suggest that prenatal and perinatal factors may influence developmental regression in ASD when interacting with genetic vulnerability. Longitudinal studies are needed to clarify the role of early environmental exposures and epigenetic mechanisms in regression patterns.
dc.identifier.doi10.1080/13651501.2025.2519522
dc.identifier.issn1365-1501
dc.identifier.issn1471-1788
dc.identifier.pmid40524611
dc.identifier.scopus2-s2.0-105008345945
dc.identifier.scopusqualityN/A
dc.identifier.urihttps://doi.org/10.1080/13651501.2025.2519522
dc.identifier.urihttps://hdl.handle.net/20.500.14704/1117
dc.identifier.wosWOS:001510631300001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTAYLOR & FRANCIS LTD
dc.relation.ispartofINTERNATIONAL JOURNAL OF PSYCHIATRY IN CLINICAL PRACTICE
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250711
dc.subjectRegressive autism
dc.subjectnon-regressive autism
dc.subjectenvironmental risk factors
dc.titleComparative analysis of regressive and non-regressive autism: a study of clinical patterns and environmental risk factors in Turkey
dc.typeArticle

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