Comparative analysis of regressive and non-regressive autism: a study of clinical patterns and environmental risk factors in Turkey

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Tarih

2025

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Yayıncı

TAYLOR & FRANCIS LTD

Erişim Hakkı

info:eu-repo/semantics/closedAccess

Özet

ObjectiveThis study compared clinical features, symptom severity, and prenatal/perinatal risk factors in children with regressive (ASD-R) and non-regressive autism spectrum disorder (ASD-NR) in a Turkish paediatric sample.MethodA retrospective cross-sectional study was conducted with 143 children aged 2-6 years diagnosed with ASD, grouped as ASD-R (n = 29) or ASD-NR (n = 114). Symptom severity was assessed using the CARS, AuBC, and ABC. Data on prenatal and perinatal factors, epilepsy, and parental age were collected.ResultsNo significant differences were found in CARS, AuBC, or total ABC scores, except for higher lethargy/social withdrawal scores in the ASD-NR group. Prenatal and perinatal risk factors and epilepsy prevalence were similar. However, parental ages at birth were significantly higher in the ASD-R group. Logistic regression did not yield significant predictors of regression.ConclusionThe findings suggest that prenatal and perinatal factors may influence developmental regression in ASD when interacting with genetic vulnerability. Longitudinal studies are needed to clarify the role of early environmental exposures and epigenetic mechanisms in regression patterns.

Açıklama

Anahtar Kelimeler

Regressive autism, non-regressive autism, environmental risk factors

Kaynak

INTERNATIONAL JOURNAL OF PSYCHIATRY IN CLINICAL PRACTICE

WoS Q Değeri

N/A

Scopus Q Değeri

N/A

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