DNA repair gene OGG1 polymorphism and its relation with oxidative DNA damage in patients with Alzheimer's disease

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dc.authoridDincer, Yildiz/0000-0002-8393-7901
dc.authoridGUVEN, MEHMET/0000-0002-8749-1708
dc.authoridMutlu, Tuba/0000-0003-3601-6074
dc.authoridYAVUZER, SERAP/0000-0001-7618-9987
dc.authoridAkkaya Engin, Caglayan/0000-0002-1905-0775
dc.contributor.authorDincer, Yildiz
dc.contributor.authorAkkaya, Caglayan
dc.contributor.authorMutlu, Tuba
dc.contributor.authorYavuzer, Serap
dc.contributor.authorErkol, Gokhan
dc.contributor.authorBozluolcay, Melda
dc.contributor.authorGuven, Mehmet
dc.date.accessioned2025-03-26T17:35:08Z
dc.date.available2025-03-26T17:35:08Z
dc.date.issued2019
dc.departmentİstanbul Esenyurt Üniversitesi
dc.description.abstractThere is considerable evidence that oxidative DNA damage is increased, DNA repair capacity is decreased in patients with Alzheimer's disease. Base excision repair is the major pathway in removal of oxidative DNA damage. 8-oxo-deoxyguanosine DNA glycosylase 1 (OGG1) is the enzyme which is involved in the first step of this repair process. Alterations in DNA repair capacity may be related with polymorphisms in DNA repair genes. In order to investigate the effect of OGG1 Ser326Cys polymorphism on oxidative DNA damage level, OGG1 genotyping was performed, basal and oxidative DNA damage in lymphocytes and 8-OHdG level in plasma were examined in patients with Alzheimer's disease. Basal and oxidative DNA damage and 8-OHdG level were measured by OGG1-modified comet assay and enzyme-linked immunoassay, respectively. OGG1 genotyping was performed by polymerase chain reaction- restriction fragment length polymorphism assay. Basal and oxidative DNA damage and plasma 8-OHdG levels were found to be higher in the Alzheimer's disease group than those in the control group (P < 0.001). In the Alzheimer's disease group, the levels of oxidative DNA damage was higher in the patients having OGG1 (Ser326Cys + Cys326Cys) genotype than those in the patients having OGG1 Ser326Ser genotype. It was concluded that oxidative DNA damage is increased in patients with Alzheimer's disease and OGG1 Ser326Cys polymorphism may be responsible for this increase.
dc.description.sponsorshipIstanbul University Scientific Research Projects Unit [TSA-2017-25458]
dc.description.sponsorshipThis work was supported and funded by Istanbul University Scientific Research Projects Unit (Project No: TSA-2017-25458)
dc.identifier.doi10.1016/j.neulet.2019.134362
dc.identifier.issn0304-3940
dc.identifier.issn1872-7972
dc.identifier.pmid31299287
dc.identifier.scopus2-s2.0-85069613252
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1016/j.neulet.2019.134362
dc.identifier.urihttps://hdl.handle.net/20.500.14704/1055
dc.identifier.volume709
dc.identifier.wosWOS:000487173200012
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier Ireland Ltd
dc.relation.ispartofNeuroscience Letters
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20250326
dc.subjectAlzheimer's disease; Oxidative DNA damage; DNA repair; OGG1 polymorphism; 8-Hydroxydeoxyguanosine
dc.titleDNA repair gene OGG1 polymorphism and its relation with oxidative DNA damage in patients with Alzheimer's disease
dc.typeArticle

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