Serum autotaxin levels correlate with the severity of pruritus in intrahepatic cholestasis of pregnancy

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dc.contributor.authorSüzen Çaypınar, Sema
dc.contributor.authorOğlak, Süleyman Cemil
dc.contributor.authorBehram, Mustafa
dc.contributor.authorGedik Özköse, Zeynep
dc.contributor.authorSezer, Salim
dc.contributor.authorKarakaş, Sema
dc.date.accessioned2025-03-26T16:10:00Z
dc.date.available2025-03-26T16:10:00Z
dc.date.issued2022
dc.departmentİstanbul Esenyurt Üniversitesi
dc.description.abstractPurpose: This study aimed to examine autotaxin (ATX) concentrations in the serum of pregnant women complicated with intrahepatic cholestasis of pregnancy (ICP) and compare them with individuals with uncomplicated healthy pregnancies. Methods: This prospective case–control study took place with 83 pregnant women. The study group included 43 pregnant women presenting with a singleton pregnancy diagnosed with ICP in their third trimester of pregnancy. The diagnostic power of the ATX variable was examined by receiver operating characteristic analysis, and the cut-off value calculated according to the Youden index was summarized with the related sensitivity and specificity points. Results: The mean serum concentration of maternal ATX was significantly higher in the ICP cases (8.91 ± 2.69 pg/mL) compared to the pregnant women in the control group (3.59 ± 1.39 ng/mL, p < 0.001). According to the Youden index, a 5.80 ng/mL cut-off value of serum ATX concentrations can be used to diagnose ICP with 97.7% sensitivity and 97.5% specificity. A significant highly positive correlation was found between maternal serum ATX levels and maternal serum total bile acid levels (r = 0.633 and p < 0.001) and itch intensity, which was objectified by the visual analog scale score (r = 0.951 and p < 0.001). Conclusion: Maternal serum ATX levels were significantly increased in ICP patients as compared with healthy pregnant women. Also, serum ATX activity was highly correlated with the itch intensity. We consider that ATX might represent a robust, accurate, and reliable circulating biomarker to diagnose ICP. © 2022 Japan Society of Obstetrics and Gynecology.
dc.identifier.doi10.1111/jog.15444
dc.identifier.endpage3102
dc.identifier.issn1341-8076
dc.identifier.issue12
dc.identifier.pmid36164271
dc.identifier.scopus2-s2.0-85138711226
dc.identifier.scopusqualityQ2
dc.identifier.startpage3093
dc.identifier.urihttps://doi.org/10.1111/jog.15444
dc.identifier.urihttps://hdl.handle.net/20.500.14704/766
dc.identifier.volume48
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherJohn Wiley and Sons Inc
dc.relation.ispartofJournal of Obstetrics and Gynaecology Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_Scopus_20250326
dc.subjectgastrointestinal and hepatic
dc.subjectobstetrics: medical problems in pregnancy
dc.titleSerum autotaxin levels correlate with the severity of pruritus in intrahepatic cholestasis of pregnancy
dc.typeArticle

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