Antimicrobial resistance of Helicobacter pylori strains to five antibiotics, including levofloxacin, in Northwestern Turkey

Basit Öğe Kaydı
dc.authoridBal, Kadir/0000-0003-3093-9070
dc.authoridbahar tokman, hrisi/0000-0002-2205-5120
dc.authoridCAKAN, HUSEYIN/0000-0003-0574-3578
dc.authoridAKGUL, OZER/0000-0002-3802-3270
dc.authoridDemirci, Mehmet/0000-0001-9670-2426
dc.authoridKALAYCI YUKSEK, FATMA/0000-0002-0028-5646
dc.authoridKocazeybek, Bekir S/0000-0003-1072-3846
dc.contributor.authorCaliskan, Reyhan
dc.contributor.authorTokman, Hrisi Bahar
dc.contributor.authorErzin, Yusuf
dc.contributor.authorSaribas, Suat
dc.contributor.authorYuksel, Pelin
dc.contributor.authorBolek, Bora Kazim
dc.contributor.authorSevuk, Ecehan Ozge
dc.date.accessioned2025-03-26T17:34:50Z
dc.date.available2025-03-26T17:34:50Z
dc.date.issued2015
dc.departmentİstanbul Esenyurt Üniversitesi
dc.description.abstractIntroduction: Antibiotic resistance is the main factor that affects the efficacy of current therapeutic regimens against Helicobacter pylori. This study aimed to determine the rates of resistance to efficacy clarithromycin, amoxicillin, tetracycline, levofloxacin and metronidazole among H. pylori strains isolated from Turkish patients with dyspepsia. Methods: H. pylori was cultured from corpus and antrum biopsies that were collected from patients with dyspeptic symptoms, and the antimicrobial susceptibility of H. pylori was determined using the E-test (clarithromycin, amoxicillin, tetracycline, metronidazole and levofloxacin) according to the EUCAST breakpoints. Point mutations in the 23S rRNA gene of clarithromycin-resistant strains were investigated using real-time PCR. Results: A total of 98 H. pylori strains were isolated, all of which were susceptible to amoxicillin and tetracycline. Of these strains, 36.7% (36/98) were resistant to clarithromycin, 35.5% (34/98) were resistant to metronidazole, and 29.5% (29/98) were resistant to levofloxacin. Multiple resistance was detected in 19.3% of the isolates. The A2143G and A2144G point mutations in the 23S rRNA-encoding gene were found in all 36 (100%) of the clarithromycin-resistant strains. Additionally, the levofloxacin MIC values increased to 32 mg/L in our H. pylori strains. Finally, among the clarithromycin-resistant strains, 27.2% were resistant to levofloxacin, and 45.4% were resistant to metronidazole. Conclusions: We conclude that treatment failure after clarithromycin-or levofloxacin-based triple therapy is not surprising and that metronidazole is not a reliable agent for the eradication of H. pylori infection in Turkey.
dc.description.sponsorshipIstanbul University Research Fund [20594]
dc.description.sponsorshipThis work was supported by the Istanbul University Research Fund under project number 20594. We are grateful for this support.
dc.identifier.doi10.1590/0037-8682-0027-2015
dc.identifier.endpage284
dc.identifier.issn0037-8682
dc.identifier.issue3
dc.identifier.pmid26108005
dc.identifier.scopus2-s2.0-84933041136
dc.identifier.scopusqualityQ2
dc.identifier.startpage278
dc.identifier.urihttps://doi.org/10.1590/0037-8682-0027-2015
dc.identifier.urihttps://hdl.handle.net/20.500.14704/922
dc.identifier.volume48
dc.identifier.wosWOS:000356868300008
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSoc Brasileira Medicina Tropical
dc.relation.ispartofRevista Da Sociedade Brasileira De Medicina Tropical
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20250326
dc.subjectHelicobacter pylori; Levofloxacin; Clarithromycin; Amoxicillin; Tetracycline; Metronidazole
dc.titleAntimicrobial resistance of Helicobacter pylori strains to five antibiotics, including levofloxacin, in Northwestern Turkey
dc.typeArticle

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu