Comparison of antagonist mild and long agonist protocols in terms of follicular fluid total antioxidant capacity

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dc.authoridocal, kutsiye pelin/0000-0002-7531-5942
dc.authoridSOFIYEVA, NIGAR/0000-0002-9998-4040
dc.authoridIREZ, TULAY/0000-0001-8272-4931
dc.authoridVARDAGLI, DUYGU/0000-0002-9022-1338
dc.contributor.authorMathyk, Begum Aydogan
dc.contributor.authorCetin, Berna Asian
dc.contributor.authorVardagli, Duygu
dc.contributor.authorZengin, Emel
dc.contributor.authorSofiyeva, Nigar
dc.contributor.authorIrez, Tulay
dc.contributor.authorOcal, Pelin
dc.date.accessioned2025-03-26T17:35:10Z
dc.date.available2025-03-26T17:35:10Z
dc.date.issued2018
dc.departmentİstanbul Esenyurt Üniversitesi
dc.description.abstractObjective: A high dose of prolonged gonadotropins can yield higher numbers of oocytes and embryos. The high dose or prolonged regimens can be associated with ovarian hyperstimulation syndrome (OHSS), multiple gestations, emotional stress, economical burden and treatment dropout. In mild stimulation lower doses and shorter duration times of gonadotropin are used in contrast to the conventional long stimulation protocol in IVF. It has been proposed that supraphysiologic levels of hormones may adversely affect endometrium and oocyte/embryo. Also it has been proposed that oxidative stress (OS) may alter ovarian hormone dynamics and could be further affected by additional exogenous hormonal stimulation. Therefore our aim was to compare follicular fluid total antioxidant capacity (TAC) in antagonist mild and long agonist stimulations. Materials and Methods: Forty patients received antagonist mild stimulation, starting on the 5th day of their cycle and forty patients received long agonist treatment. Seventy-five patients undergoing their first IVF cycle were included in the final analysis. Follicular fluid (FF) samples were analyzed for estradiol (E2), antimullerian hormone (AMH) and TAC. Results: FF-Total antioxidant capacity (TAC) levels were higher in the long agonist group as opposed to the antagonist group [1.07 +/- 0.04 mmol Trolox equivalent/L vs 1 +/- 0.13 mmol Trolox equivalent/L] (Fig. 1). Pregnancy rates were not significantly different between the two treatments. The FF-TAC levels were not different among infertility etiologies (Fig. 3). FF-TAC levels did not have a direct correlation with pregnancy but a positive correlation with the total gonadotropin dose was observed. Conclusion: Patients with good ovarian reserves and under the age of 35 effectively responded to mild stimulation treatment. Using lower amounts of gonadotropin, yielded less FF-TAC levels in patients who underwent antagonist mild protocol. In patients under the age of 35, antagonist mild stimulation is a patient friendly and effective procedure when undergoing their first IVF cycle. (C) 2018 Taiwan Association of Obstetrics & Gynecology. Publishing services by Elsevier B.V.
dc.description.sponsorshipIstanbul University Scientific Research Projects [4562]
dc.description.sponsorshipThis study was funded by Istanbul University Scientific Research Projects (project number: 4562).
dc.identifier.doi10.1016/j.tjog.2018.02.005
dc.identifier.endpage199
dc.identifier.issn1028-4559
dc.identifier.issue2
dc.identifier.pmid29673660
dc.identifier.scopus2-s2.0-85042587377
dc.identifier.scopusqualityQ2
dc.identifier.startpage194
dc.identifier.urihttps://doi.org/10.1016/j.tjog.2018.02.005
dc.identifier.urihttps://hdl.handle.net/20.500.14704/1084
dc.identifier.volume57
dc.identifier.wosWOS:000441326400005
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier Taiwan
dc.relation.ispartofTaiwanese Journal of Obstetrics & Gynecology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20250326
dc.subjectAnti mullerian hormone (AMH); Follicular fluid; In vitro fertilization (IVF); Mild stimulation; Total antioxidant capacity (TAC)
dc.titleComparison of antagonist mild and long agonist protocols in terms of follicular fluid total antioxidant capacity
dc.typeArticle

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