Increased maternal serum aquaporin 9 levels in pregnancies complicated with gestational diabetes mellitus

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dc.authoridKaya, Serdar/0000-0002-4092-7316
dc.authoridsezer, salim/0000-0003-1287-4306
dc.contributor.authorSezer, Salim
dc.contributor.authorKaya, Serdar
dc.contributor.authorBehram, Mustafa
dc.contributor.authorDag, Ismail
dc.date.accessioned2025-03-26T17:34:58Z
dc.date.available2025-03-26T17:34:58Z
dc.date.issued2022
dc.departmentİstanbul Esenyurt Üniversitesi
dc.description.abstractIntroduction This study aimed to examine maternal serum aquaporin 9 levels in pregnant women with gestational diabetes mellitus and to compare them with non-diabetic pregnant women. Methods Forty-one pregnant women between 37 and 39 weeks of gestation complicated with gestational diabetes mellitus and 39 non-diabetic pregnant women at similar gestational weeks without additional obstetric complications were included in this cross-sectional study. Maternal serum aquaporin 9 levels and leptin levels of the cases were measured. Results Maternal serum leptin and aquaporin 9 levels in pregnant women with GDM were found to be significantly higher than in the control group (p < .001). In the study group, first-minute Apgar scores were significantly lower and birth weight significantly higher (p = .001 and .005, respectively). A weak but significant positive correlation between aquaporin 9 levels and maternal body mass index (r = 0.279, p = .012), birth weight (r = 0.433, p < .001), and hemoglobin A1c (r = 0.354, p = .001) levels was detected. A significant positive correlation was detected between maternal serum aquaporin 9 levels and leptin levels (r = 0.331, p = .003). Conclusion The increased aquaporin 9 levels detected in cases with gestational diabetes mellitus might be a marker of the poor maternal metabolic environment specific to diabetes and might contribute to the pathophysiology of gestational diabetes.
dc.identifier.doi10.1080/14767058.2021.1970131
dc.identifier.endpage23
dc.identifier.issn1476-7058
dc.identifier.issn1476-4954
dc.identifier.issue1
dc.identifier.pmid34470136
dc.identifier.scopus2-s2.0-85113740824
dc.identifier.scopusqualityQ1
dc.identifier.startpage18
dc.identifier.urihttps://doi.org/10.1080/14767058.2021.1970131
dc.identifier.urihttps://hdl.handle.net/20.500.14704/975
dc.identifier.volume35
dc.identifier.wosWOS:000690835700001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTaylor & Francis Ltd
dc.relation.ispartofJournal of Maternal-Fetal & Neonatal Medicine
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20250326
dc.subjectAquaporin 9; gestational diabetes mellitus; perinatal outcome; maternal metabolism; aquaglyceroporins
dc.titleIncreased maternal serum aquaporin 9 levels in pregnancies complicated with gestational diabetes mellitus
dc.typeArticle

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