Activation of BDNF- and VEGF-mediated Neuroprotection by Treadmill Exercise Training in Experimental Stroke

Basit Öğe Kaydı
dc.authoridEGHBAL MOGHANLOU, Abdorreza/0000-0003-1238-0541
dc.authoridFaghfoori, Zeinab/0000-0002-5312-6585
dc.contributor.authorSayyah, Mansour
dc.contributor.authorSeydyousefi, Mehdi
dc.contributor.authorMoghanlou, Abdorreza Eghbal
dc.contributor.authorMetz, Gerlinde A. S.
dc.contributor.authorShamsaei, Nabi
dc.contributor.authorFaghfoori, Mohammad Hasan
dc.contributor.authorFaghfoori, Zeinab
dc.date.accessioned2025-03-26T17:35:02Z
dc.date.available2025-03-26T17:35:02Z
dc.date.issued2022
dc.departmentİstanbul Esenyurt Üniversitesi
dc.description.abstractEarly treatment of ischemic stroke is one of the most effective ways to reduce brains' cell death and promote functional recovery. This study was designed to examine the effect of aerobic exercise on post ischemia/reperfusion injury on concentration and expression of brain-derived neurotrophic factor (BDNF) and vascular endothelial growth factor (VEGF) after inducing a neuronal loss in CA1 region of hippocampus in Male Wistar rats. Three experimental groups including sham(S), ischemia/reperfusion-control (IRC) and ischemia/reperfusion exercise (IRE) were used for this purpose. The rats in the IRE group received a bilateral carotid artery occlusion treatment. They ran for 45 minutes on a treadmill five days per week for eight consecutive weeks. Cresyl violet (Nissl), Hematoxylin (H & E) and Eosin staining procedure were used to determine the extent of damage. A ladder rung walking task was used to assess the functional impairments and recovery after the ischemic lesion. ELISA and immunohistochemistry method were employed to measure BDNF and VEGF protein expressions. The result showed that the brain ischemia/reperfusion condition increased the cell death in hippocampal CA1 neurons and impaired motor performance on the ladder rung task whereas the aerobic exercise program significantly decreased the brain cell's death and improved motor skill performance. It was concluded that ischemic brain lesion decreased the BDNF and VEGF expression. It seems that the aerobic exercise following the ischemia/reperfusion potentially promotes neuroprotective mechanisms and neuronal repair and survival mediated partly by BDNF and other pathways.
dc.description.sponsorshipSemnan University of Medical Sciences, Semnan, Iran [A-10-377-2]
dc.description.sponsorshipThis work was supported by the Semnan University of Medical Sciences, Semnan, Iran [grant number A-10-377-2].
dc.identifier.doi10.1007/s11011-022-01003-7
dc.identifier.endpage1853
dc.identifier.issn0885-7490
dc.identifier.issn1573-7365
dc.identifier.issue6
dc.identifier.pmid35596908
dc.identifier.scopus2-s2.0-85130250463
dc.identifier.scopusqualityQ2
dc.identifier.startpage1843
dc.identifier.urihttps://doi.org/10.1007/s11011-022-01003-7
dc.identifier.urihttps://hdl.handle.net/20.500.14704/1014
dc.identifier.volume37
dc.identifier.wosWOS:000799669500001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringer/Plenum Publishers
dc.relation.ispartofMetabolic Brain Disease
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20250326
dc.subjectEarly exercise; ischemic; reperfusion brain stroke; BDNF; VEGF
dc.titleActivation of BDNF- and VEGF-mediated Neuroprotection by Treadmill Exercise Training in Experimental Stroke
dc.typeArticle

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu