Prognostic significance of high free T4 and low free T3 levels in non-thyroidal illness syndrome

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dc.authoridAhbab, Suleyman/0000-0001-9239-9132
dc.authoridAtaoglu, Hayriye Esra/0000-0002-6559-2575
dc.authoridSecmeler, Saban/0000-0001-8421-9234
dc.contributor.authorAtaoglu, Hayriye Esra
dc.contributor.authorAhbab, Suleyman
dc.contributor.authorSerez, Mustafa Kemal
dc.contributor.authorYamak, Mehmet
dc.contributor.authorKayas, Derya
dc.contributor.authorCanbaz, Esra Turan
dc.contributor.authorCetin, Faik
dc.date.accessioned2025-03-26T17:35:00Z
dc.date.available2025-03-26T17:35:00Z
dc.date.issued2018
dc.departmentİstanbul Esenyurt Üniversitesi
dc.description.abstractBackground: Non-thyroidal illness syndrome is characterized by decreased serum free T3 (FT3) level and associates with long term mortality. Serum free T4 (FT4) may affect on mortality with FT3 in course of chronic illness. This study performed to evaluate the association between both decreased FT3 with elevated FT4 levels and mortality risk. Methods: This study is a retrospective cohort analysis and consisted up 1164 (571 male, 593 female) patients with a 36 months follow up period. Patients divided into four groups according to thyroid functions. Patients with euthyroidism were in Group A, elevated FT3 in group B, decreased FT3 in group C and both decreased FT3 and elevated FT4 levels in group D. The levels of thyroid hormones and all cause mortality were compared between four groups. Results: Mortality rate was elevated between Groups A and B, A and C, A and D, B and C, B and D, C and D, (p < .001, p < .001, p < .001, p < .001, p < .001, p:0.019, respectively). A multivariate Cox proportional hazards model was performed to evaluate the mortality risk between groups. A close relationship was observed in Group C and D patients for the mortality risk (OR:1.561, 95% CI:1.165-2.090, p:0.003 and OR:2.224, 95% CI:1.645-3.006, p:0.0001, respectively). Conclusion: Both decreased FT3 and elevated FT4 levels are independent predictor for long term mortality risk in hospitalized chronic patients with non-thyroidal illness syndrome.
dc.identifier.doi10.1016/j.ejim.2018.07.018
dc.identifier.endpage95
dc.identifier.issn0953-6205
dc.identifier.issn1879-0828
dc.identifier.pmid30029851
dc.identifier.scopus2-s2.0-85049916011
dc.identifier.scopusqualityQ1
dc.identifier.startpage91
dc.identifier.urihttps://doi.org/10.1016/j.ejim.2018.07.018
dc.identifier.urihttps://hdl.handle.net/20.500.14704/998
dc.identifier.volume57
dc.identifier.wosWOS:000449715900034
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier Science Bv
dc.relation.ispartofEuropean Journal of Internal Medicine
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20250326
dc.subjectNon thyroidal illness syndrome; Serum free T3; Serum free T4; Mortality
dc.titlePrognostic significance of high free T4 and low free T3 levels in non-thyroidal illness syndrome
dc.typeArticle

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