A Comparison of the Effects of Neuronal Nitric Oxide Synthase and Inducible Nitric Oxide Synthase Inhibition on Cartilage Damage

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dc.authoridDemiroz, Ahu Senem/0000-0002-8370-1130
dc.authoridKomur, Baran/0000-0003-2821-9859
dc.authoridYilmaz, Ibrahim/0000-0003-1503-4046
dc.authoridYILMAZ, Ibrahim/0000-0003-2003-6337
dc.authoridVural gokay, Banu/0000-0002-3147-1572
dc.contributor.authorGokay, Nevzat Selim
dc.contributor.authorYılmaz, İbrahim
dc.contributor.authorKomur, Baran
dc.contributor.authorDemiroz, Ahu Senem
dc.contributor.authorGokce, Alper
dc.contributor.authorDervisoglu, Sergulen
dc.contributor.authorGokay, Banu Vural
dc.date.accessioned2025-03-26T17:34:56Z
dc.date.available2025-03-26T17:34:56Z
dc.date.issued2016
dc.departmentİstanbul Esenyurt Üniversitesi
dc.description.abstractThe objective of this study was to investigate the effects of selective inducible nitric oxide synthase and neuronal nitric oxide synthase inhibitors on cartilage regeneration. The study involved 27 Wistar rats that were divided into five groups. On Day 1, both knees of 3 rats were resected and placed in a formalin solution as a control group. The remaining 24 rats were separated into 4 groups, and their right knees were surgically damaged. Depending on the groups, the rats were injected with intra-articular normal saline solution, neuronal nitric oxide synthase inhibitor 7-nitroindazole (50mg/kg), inducible nitric oxide synthase inhibitor aminoguanidine (30mg/kg), or nitric oxide precursor L-arginine (200mg/kg). After 21 days, the right and left knees of the rats were resected and placed in formalin solution. The samples were histopathologically examined by a blinded evaluator and scored on 8 parameters. Although selective neuronal nitric oxide synthase inhibition exhibited significant(p = 0.044) positive effects on cartilage regeneration following cartilage damage, it was determined that inducible nitric oxide synthase inhibition had no statistically significant effect on cartilage regeneration. It was observed that the nitric oxide synthase activation triggered advanced arthrosis symptoms, such as osteophyte formation. The fact that selective neuronal nitric oxide synthase inhibitors were observed to have mitigating effects on the severity of the damage may, in the future, influence the development of new agents to be used in the treatment of cartilage disorders.
dc.description.sponsorshipTurkish Orthopedic Society (TOTBID)
dc.description.sponsorshipThe authors thank the Turkish Orthopedic Society (TOTBID) for their grants (28.02.2011 date, no. 11) in support of this study. They also thank Oguz Yacan and http://www.medical-statistic.com/ for help with the statistical analysis.
dc.identifier.doi10.1155/2016/7857345
dc.identifier.issn2314-6133
dc.identifier.issn2314-6141
dc.identifier.pmid27382570
dc.identifier.scopus2-s2.0-84976631876
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1155/2016/7857345
dc.identifier.urihttps://hdl.handle.net/20.500.14704/951
dc.identifier.volume2016
dc.identifier.wosWOS:000378710200001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherHindawi Ltd
dc.relation.ispartofBiomed Research International
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20250326
dc.subjectReduced Chondrocyte Proliferation; Human Articular Chondrocytes; Experimental Osteoarthritis; Proteoglycan Turnover; Joint Pain; Expression; Apoptosis; Cytokines; Model; Degradation
dc.titleA Comparison of the Effects of Neuronal Nitric Oxide Synthase and Inducible Nitric Oxide Synthase Inhibition on Cartilage Damage
dc.typeArticle

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