High-intensity interval training and moderate intensity training with exogenous adenosine counteract development of obesity in rats

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dc.authoridEslami, Zahra/0000-0002-3187-3977
dc.authoridEGHBAL MOGHANLOU, Abdorreza/0000-0003-1238-0541
dc.contributor.authorPekkala, S.
dc.contributor.authorRafiei, M. M.
dc.contributor.authorEslami, Z.
dc.contributor.authorGhaderi, M.
dc.contributor.authorMoghanlou, A. E.
dc.contributor.authorSharifian, S.
dc.contributor.authorJaghoori, A.
dc.date.accessioned2025-03-26T17:34:58Z
dc.date.available2025-03-26T17:34:58Z
dc.date.issued2022
dc.departmentİstanbul Esenyurt Üniversitesi
dc.description.abstractObjectives. - High-Intensity Interval Training (HIIT) and Moderate Intensity Training (MIT) can combat the obesity epidemic. However, studies comparing their effects on obesity show controversial findings regarding weight loss. Adenosine has emerged as a possible, novel therapeutic agent to treat obesity, but more preclinical studies on its efficacy are needed. Therefore, theobjectives of this study were to compare the effects of HIIT and MIT on obesity, and further todetermine the dose-dependent effects of adenosine on body weight. Equipment and methods. - We induced obesity in male Wistar rats with high-fat diet (HFD) and monitored development of obesity by comparing the weight to rats on normal diet (ND). After 13 weeks of feeding, exercise training and intraperitoneal adenosine or placebo injectionsstarted. The animals were divided into the intervention groups based on equal average weight: (1) ND-1, 2) ND-2, (3) HFD, (4) HFD + placebo, (5) HFD + adenosine, (6) HFD + adenosine + HIIT, (7) HFD + placebo + HIIT, (8) HFD + adenosine + MIT, and (9) HFD + placebo + MIT. During the firstsix weeks of interventions, adenosine was injected at a dose of 0.2 mg/ml/kg and the followingsix weeks at 0.4 mg/ml/kg. Weight and feed consumption were determined, and energy intakewas calculated as kJ/day. Results. - The HFD started to cause obesity after 19 weeks of feeding. Both HIIT and MIT wereequally effective in counteracting the HFD-induced weight gain, while no differences in theeffects were found between the two exercise modes. Adenosine, independent of the dose, alsoprevented weight gain but did not enhance the effects of HIIT or MIT on weight. The obesity-counteracting effects of the treatments were not due to lower energy intake. In conclusion, our study shows that HIIT and MIT are equally effective to combat obesity, and further, providepreclinical evidence of that adenosine injections could be used to treat obesity. (c) 2022 L'Auteur(s). Publie par Elsevier Masson SAS. Cet article est publi ' e en Open Access souslicence CC BY (http://creativecommons.org/licenses/by/4.0/).
dc.description.sponsorshipAcademy of Finland [308042]; Academy of Finland (AKA) [308042] Funding Source: Academy of Finland (AKA)
dc.description.sponsorshipWe wish to acknowledge Shahid Mirghani Research Insitute for providing technical help in the animal experiments and collection of the data. We thank Markku Kauppinen from the University of Jyvaskyla, Finland for helping with the statistical analyses. Dr. Satu Pekkala was supported by the Academy of Finland Research Fellow funding (Grant ID 308042).
dc.identifier.doi10.1016/j.scispo.2021.11.001
dc.identifier.endpage485
dc.identifier.issn0765-1597
dc.identifier.issue5-6
dc.identifier.scopus2-s2.0-85125529744
dc.identifier.scopusqualityQ3
dc.identifier.startpage477
dc.identifier.urihttps://doi.org/10.1016/j.scispo.2021.11.001
dc.identifier.urihttps://hdl.handle.net/20.500.14704/982
dc.identifier.volume37
dc.identifier.wosWOS:000889069900014
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherElsevier France-Editions Scientifiques Medicales Elsevier
dc.relation.ispartofScience & Sports
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20250326
dc.subjectExogenous adenosine; High-IntensityInterval Training (HIIT); Moderate IntensityTraining (MIT); Isocaloric; Exercise; Weight loss; Energy intake; Obesity; High Fat diet (HFD)
dc.titleHigh-intensity interval training and moderate intensity training with exogenous adenosine counteract development of obesity in rats
dc.typeArticle

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