Adenosine and High-intensity Interval Training as Potential Therapies on Free Fatty Acids and Metabolic Factors in High-fat Diet-Induced Obesity in Male Wistar Rats

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dc.contributor.authorEslami, Zahra
dc.contributor.authorFallah, Ayda
dc.contributor.authorEghbal Moghanlou, Abdorreza
dc.contributor.authorBaydaş, Giyasettin
dc.contributor.authorSharifian, Shohreh
dc.contributor.authorMirghani, Seyed Javad
dc.date.accessioned2025-03-26T16:10:01Z
dc.date.available2025-03-26T16:10:01Z
dc.date.issued2025
dc.departmentİstanbul Esenyurt Üniversitesi
dc.description.abstractObesity, caused by an inequality between energy production and consumption, is characterized by lipid accumulation in adipose tissues. Currently, around 650 million adults and roughly 340 million children and adolescents (aged 5-19 years) are affected by obesity. This condition tends to be more common among women and older populations. It is imperative to develop uncomplicated therapeutic approaches to prevent obesity-related metabolic diseases in conjunction with lifestyle modifications. Forty-three rats were randomly divided into five groups: 1. normal diet (ND), 2. High-fat diet (HFD), 3. HFD + adenosine, 4. HFD + High-intensity interval training (HIIT) + adenosine, and 5. HFD + HIIT. Gene expression of CGI-58, HSL, and AMPK in subcutaneous adipose tissues and serum level of glucose, insulin, Homeostatic Model Assessment for Insulin Resistance (HOMA-IR), free fatty acid (FFA), and lipid profile (Triglyceride (TG), Total cholesterol (TC), Low density lipoprotein (LDL), High density lipoprotein (HDL), and Very low density lipoprotein (VLDL)) were assessed. The rats were fed HFD-induced obesity for 13 weeks. Following, adenosine 0.2 mg/ml/kg and 0.4 mg/ml/kg, as well as HIIT, were administered over 12 weeks. CGI-58, HSL and AMPK gene expression showed significant expression in all groups. HFD+HIIT+adenosine, HFD+adenosine, and HFD+HIIT groups significantly increased all genes. Conversely, FFA and glucose serum levels were significantly reduced in intervention groups. Insulin had higher serum levels in ND, HFD + adenosine, and HFD+HIIT groups, and adenosine caused decreased glucose. Also, favorable effects of HIIT and adenosine on lipid profile were observed. HIIT and adenosine can affect lipid metabolism, improve insulin resistance, and increase lipolysis in adipose tissue. Furthermore, adenosine can boost the effect of HIIT on gene expression, triggering lipolysis to prevent obesity. © 2025, Iranian Association of Pharmaceutical Scientists. All rights reserved.
dc.identifier.doi10.22037/ijps.v21i1.46498
dc.identifier.endpage98
dc.identifier.issn1735-2444
dc.identifier.issue1
dc.identifier.scopus2-s2.0-85219685550
dc.identifier.scopusqualityQ4
dc.identifier.startpage89
dc.identifier.urihttps://doi.org/10.22037/ijps.v21i1.46498
dc.identifier.urihttps://hdl.handle.net/20.500.14704/781
dc.identifier.volume21
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherIranian Association of Pharmaceutical Scientists
dc.relation.ispartofIranian Journal of Pharmaceutical Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_Scopus_20250326
dc.subjectAdenosine
dc.subjectAdipose tissue
dc.subjectHigh intensity interval training
dc.subjectHigh-fat diet
dc.subjectLipid
dc.titleAdenosine and High-intensity Interval Training as Potential Therapies on Free Fatty Acids and Metabolic Factors in High-fat Diet-Induced Obesity in Male Wistar Rats
dc.typeArticle

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