The OGG1 Ser326Cys polymorphism and its association with DNA damage and DNA repair in papillary thyroid cancer

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dc.contributor.authorAkkaya Engin, Çağlayan
dc.contributor.authorYavuzer, Hakan
dc.contributor.authorTeksöz, Serkan
dc.contributor.authorSoylu, Selen
dc.contributor.authorMete, Meltem
dc.contributor.authorYavuzer, Serap
dc.contributor.authorTuz, Ali Ata
dc.date.accessioned2025-07-23T20:43:35Z
dc.date.available2025-07-23T20:43:35Z
dc.date.issued2025
dc.departmentİstanbul Esenyurt Üniversitesi
dc.description.abstractAim: Hydrogen peroxide, locally produced during thyroid hormone synthesis, leads to oxida- tive stress in the thyroid gland. Defective repair of oxidative DNA lesions contributes to tumor development. This study aimed to understand the importance of DNA damage and repair on thyroid cancer development through the impact of the DNA repair gene OGG1 Ser326Cys polymorphism that has clinical significance in untreated patients with papillary thyroid can- cer. Methods: The study was performed with 70 patients with papillary thyroid cancer and 73 vol- unteers as control. In lymphocytes, endogenous DNA damage, H2O2-induced DNA damage, and DNA damage after repair were determined by comet assay. The polymerase chain reac- tion-restriction fragment length polymorphism method was performed for OGG1 genotyping. Results: Endogenous DNA damage, H2O2-induced DNA damage, and DNA damage after re- pair were higher in patients with thyroid cancer than in the controls (P<0.001). An association was determined between the OGG1 Cys326 allele and increased risk for the development of papillary thyroid cancer. No significant difference was determined between cases carrying different OGG1 genotypes for endogenous DNA damage, H2O2-induced DNA damage, and DNA damage after repair in the study groups. Conclusions: Endogenous DNA damage and cell susceptibility to oxidation increase, and DNA repair is impaired in patients with papillary thyroid cancer. However, the OGG1 Ser - 326Cys polymorphism is not responsible for the DNA repair defect.
dc.identifier.doi10.21673/anadoluklin.1508336
dc.identifier.endpage8
dc.identifier.issn2149-5254
dc.identifier.issn2458-8849
dc.identifier.issue1
dc.identifier.startpage1
dc.identifier.trdizinid1298575
dc.identifier.urihttps://doi.org/10.21673/anadoluklin.1508336
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1298575
dc.identifier.urihttps://hdl.handle.net/20.500.14704/1111
dc.identifier.volume30
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.relation.ispartofANADOLU KLİNİĞİ TIP BİLİMLERİ DERGİSİ
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.snmzKA_TR-Dizin_20250711
dc.subjectDNA damage
dc.subjectpolymorphism
dc.subjectDNA repair
dc.subjectthyroid neoplasm
dc.titleThe OGG1 Ser326Cys polymorphism and its association with DNA damage and DNA repair in papillary thyroid cancer
dc.typeArticle

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