The Impact of Early Childhood Adversity on Neurodevelopment: A Comprehensive Review

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dc.contributor.authorAlpuğan, Zeynep
dc.date.accessioned2025-03-26T13:52:50Z
dc.date.available2025-03-26T13:52:50Z
dc.date.issued2024
dc.departmentİstanbul Esenyurt Üniversitesi
dc.description.abstractEarly childhood is a vital period for brain development, characterized by rapid growth and high plasticity. Adverse experiences during this time, such as abuse, neglect, violence, and poverty, can significantly affect neurodevelopment and have lasting impacts on mental health and behavior. This review explores the influence of early adversity on brain development, emphasizing key mechanisms and outcomes. Research indicates that early adversity causes alterations in brain regions like the prefrontal cortex, amygdala, hippocampus, and corpus callosum, impairing cognitive functions such as learning, memory, and executive functioning. Chronic stress disrupts the hypothalamic-pituitary-adrenal (HPA) axis, resulting in elevated cortisol levels that hinder emotional regulation and heighten the risk of mental health disorders such as depression and anxiety. Epigenetic changes show how adversity can modify gene expression, affecting brain development without altering the DNA sequence. The repercussions of early adversity include cognitive deficits, emotional and behavioral problems, and social development challenges. However, resilience factors, including individual traits and supportive environments, can mitigate these negative impacts. Robust study designs, such as longitudinal and multidisciplinary approaches, are crucial for understanding the long-term effects of early adversity. Ethical considerations and precise measurement are vital for protecting vulnerable populations. Policy implications suggest that findings should inform child welfare, education, and mental health policies, focusing on early identification and intervention. Practitioners should adopt trauma-informed approaches, implement early intervention programs, and support parents and caregivers. Addressing early childhood adversity is crucial for promoting healthy neurodevelopment and well-being. Comprehensive interventions can reduce adverse effects, support healthy development, and contribute to a resilient society.
dc.identifier.doi10.32739/uha.jnbs.11.1539116
dc.identifier.doihttps://doi.org/10.32739/uha.jnbs.11.1539116
dc.identifier.endpage59
dc.identifier.issn2149-1909
dc.identifier.issn2148-4325
dc.identifier.issue2
dc.identifier.startpage45
dc.identifier.urihttps://hdl.handle.net/20.500.14704/308
dc.identifier.volume11
dc.institutionauthorAlpuğan, Zeynep
dc.language.isoen
dc.publisherUskudar University
dc.relation.ispartofThe Journal of Neurobehavioral Sciences
dc.relation.publicationcategoryDiğer
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_DergiPark_20250326
dc.subjectEarly Childhood Adversity
dc.subjectNeurodevelopment
dc.subjectBrain Development
dc.subjectAbuse
dc.subjectNeglect
dc.titleThe Impact of Early Childhood Adversity on Neurodevelopment: A Comprehensive Review
dc.typeReview

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