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    Effects of Blood Hemoglobin Levels on Vertebral Discal Degeneration
    (2023) Cetin, Eyup; Şah, Volkan; Arslan, Mustafa; Arabacı, Ozkan; Akyol, Mehmet Edip; Ünlü, İlker
    Introduction: Vertebral discopathies are one of the most important causes of low back pain, which is very common in the community. Although there are many biochemical and mechanical causes of discogenic low back pain, the most important is discal degeneration. Many studies have been conducted suggesting that disc degeneration could be associated with various factors. In our study, we aimed to reveal a possible relationship between disc degeneration and levels of hemoglobin (HGB). Methods: We investigated the connection between discal degeneration and certain parameters, especially HGB levels, in a total of 174 patients in two separate groups; those with and without disc degeneration. Age, weight, height, body mass index, chronic diseases, mean HGB, hematocrit (HTC) level, white blood cell (WBC), high-density lipoprotein, low-density lipoprotein (LDL), and triglyceride (TG) values of the patients were recorded. Results: No significant difference was detected (p>0.05) between the groups with and without degeneration in terms of HGB, HTC, WBC, and LDL values. The TG level in the group with disc degeneration was significantly (p<0.05) higher than the group without disc degeneration. Discussion and Conclusion: Lumbar disc degeneration is a public health problem that continues to be discussed in the literature. There was no significant difference in terms of HGB levels between the groups, with and without degenerated disc.
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    Histopathological and immunohistochemical investigation of the effect of Shilajit in rats with experimental spinal cord injury
    (Turkish Assoc Trauma Emergency Surgery, 2023) Cetin, Eyup; Sancak, Tunahan; Keles, Omer Faruk; Unlu, Ilker; Akyol, Mehmet Edip; Arabacı, Ozkan
    BACKGROUND: This experimental study was designed to investigate the histopathological and immunohistochemical effects of Shilajit in rats with experimentally induced spinal cord injury (SCI). METHODS: The rats were divided into three groups: Control group: The group in which spinal cord damage was created but no drug was administered. Low-dose group: This is the group in which intraperitoneal Shilajit is given at a dose of 150 mg/kg at the 1st h, 1st day, 2nd day, and 3rd day after spinal cord damage was induced. High-dose group: This is the group in which intraperitoneal Shilajit is given at a dose of 250 mg/kg at the 1st h, 1st day, 2nd day, and 3rd day after spinal cord damage was induced. Thin sections taken from the spinal cord after euthanasia were sent for histopathological and immunohistochemical examination. RESULTS: Histopathological examination of the high-dose group showed lower amounts of morphological findings compared to the low-dose group and control group. While a significant CD68 immune reaction was observed in the control group of rats with spinal injury, the positive immune reaction was found to be significantly decreased in the Shilajit-applied groups. CONCLUSION: It is thought that the use of Shilajit in SCI will reduce the effects of secondary damage in SCI and that its administration to such patients will have positive effects on the results.